The synthesis of dextroamphetamine involves solid multi-step process starting from D-phenylalanine https://eurekathinklabs.com/dextroamphetamine-decoding-the-chemistry-and-medicinal-significance/

Starting Material: The synthesis begins with D-phenylalanine, koiu serves as the precursor for the production of dextroamphetamine sulfate and methamphetamine hydrochloride.

Reaction Sequence: The reaction sequence proceeds through three intermediates, involving the alteration of the absolute configuration of the asymmetric carbon atom while maintaining the comparative configuration. This process pulls to the formation of dextroamphetamine sulfate besides methamphetamine hydrochloride.

Intermediate Alteration: The synthesis involves altering the reductive conditions employed for the removal of a carbamate protecting group to obtain or dextroamphetamine sulfate or methamphetamine hydrochloride from solid frequent intermediate.

Specific Chemical Reactions: The characteristic chemical reactions involved in the synthesis include the conversion of benzene into allylbenzene, replacement of all CN group to forms the cyano compound, reduction in order to an amine, besides elongation of the chain using alkynyl anion in order to shape an alkene.

Patent Information: There is patent-related information available regarding the process for the synthesis of amphetamine derivatives, covering dexamphetamine, applying special reaction conditions and coupling agents.

Literature References: The synthesis process owns happened documented in scientific fiction, even the Journal of Pharmaceutical Sciences, with thorough information about the synthesis of dextroamphetamine sulfate besides methamphetamine hydrochloride from D-phenylalanine.